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Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis.
Ding D, Valdivia AO, Bhattacharya SK. Ding D, et al. Metab Brain Dis. 2020 Feb;35(2):275-282. doi: 10.1007/s11011-019-00515-z. Epub 2019 Dec 10. Metab Brain Dis. 2020. PMID: 31823109
In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associated with increased levels of nuclear prelamin A reco …
In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblo …
NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification.
Yang Y, Chen C, Zuo Q, Lu H, Salman S, Lyu Y, Huang TY, Wicks EE, Jackson W 3rd, Datan E, Wang R, Wang Y, Le N, Zhu Y, Qin W, Semenza GL. Yang Y, et al. Sci Adv. 2022 Dec 9;8(49):eabo5000. doi: 10.1126/sciadv.abo5000. Epub 2022 Dec 9. Sci Adv. 2022. PMID: 36490339 Free PMC article.
Hypoxia is a key characteristic of the breast cancer microenvironment that promotes expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1) and is associated with poor patient outcome. HIF-1 increases the expression or activity of stem cell pluripote …
Hypoxia is a key characteristic of the breast cancer microenvironment that promotes expression of the transcriptional activator hypoxia-indu …
RNA-editing-mediated exon evolution.
Lev-Maor G, Sorek R, Levanon EY, Paz N, Eisenberg E, Ast G. Lev-Maor G, et al. Genome Biol. 2007;8(2):R29. doi: 10.1186/gb-2007-8-2-r29. Genome Biol. 2007. PMID: 17326827 Free PMC article.
It was recently shown that Alu elements are also heavily changed by RNA editing in the human genome. RESULTS: Here we show that the human nuclear prelamin A recognition factor contains a primate-specific Alu-exon that exclusively depends on RNA …
It was recently shown that Alu elements are also heavily changed by RNA editing in the human genome. RESULTS: Here we show that the human …
Microarray analysis of retinal gene expression in Egr-1 knockout mice.
Schippert R, Schaeffel F, Feldkaemper MP. Schippert R, et al. Mol Vis. 2009 Dec 10;15:2720-39. Mol Vis. 2009. PMID: 20019881 Free PMC article.
Changes in four of the ten genes could be confirmed by real-time RT-PCR: nuclear prelamin A recognition factor (Narf), oxoglutarate dehydrogenase (Ogdh), selenium binding protein 1 (Selenbp1), and Pcdhb9. ...In addition to these genes, th …
Changes in four of the ten genes could be confirmed by real-time RT-PCR: nuclear prelamin A recognition facto …
Beyond DNA: RNA editing and steps toward Alu exonization in primates.
Möller-Krull M, Zemann A, Roos C, Brosius J, Schmitz J. Möller-Krull M, et al. J Mol Biol. 2008 Oct 10;382(3):601-9. doi: 10.1016/j.jmb.2008.07.014. Epub 2008 Jul 16. J Mol Biol. 2008. PMID: 18680752
Adenosine-to-inosine (A-to-I) modification is a recently discovered, RNA-editing-mediated mechanism that contributes to the exonization of previously unprocessed mRNA introns. In the human nuclear prelamin A recognition factor gene transcript, t …
Adenosine-to-inosine (A-to-I) modification is a recently discovered, RNA-editing-mediated mechanism that contributes to the exonization of p …